Rhea Clindamycin Hydrochloride

Clindamycin HCl

Infections of upper & lower resp tract, GUT, skin & soft tissue, bone & joint, gynecological, intra-abdominal, dental eg, periodontal abscess & periodontitis; septicemia & endocarditis; toxoplasmic encephalitis & Pneumocystis jirovecii pneumonia in patients w/ AIDS. Malaria in combination w/ quinine. Prophylaxis of endocarditis in patients sensitive/allergic to penicillin.

Adult 600-1,800 mg/day divided in 2, 3 or 4 equal doses. Childn >1 mth 8-25 mg/kg/day in 3 or 4 equal doses. β-hemolytic streptococcal infection Treatment should be continued for at least 10 days. Pelvic inflammatory disease (inpatient) Clindamycin phosphate 900 mg IV every 8 hr daily + antibiotic w/ appropriate gm -ve aerobic spectrum IV eg, gentamicin 2 mg/kg followed by 1.5 mg/kg every 8 hr daily in patients w/ normal renal function. Continue IV for at least 4 days & at least 48 hr after patient improves. Then continue oral clindamycin HCl 450-600 mg every 6 hr daily to complete 10-14 total therapy. Chlamydia trachomatis cervicitis 450-600 mg qid for 10-14 days. Toxoplasmic encephalitis in patients w/ AIDS 600-1,200 mg every 6 hr for 2 wk followed by 300-600 mg every 6 hr in 8-10 wk. Pneumocystis carinii pneumonia in patients w/ AIDS Clindamycin phosphate 600-900 mg IV every 6 hr or 900 mg every 8 hr or Clindamycin HCl 300-450 mg every 6 hr for 21 days & primaquine 15-30 mg once daily for 21 days. Acute streptococcal tonsillitis/pharyngitis 300 mg bid for 10 days. Uncomplicated malaria/Plasmodium falciparum Adult Quinine sulfate 650 mg tid for 3 or 7 days + clindamycin 20 mg base/kg/day divided tid for 7 days. Childn Quinine sulfate 10 mg/kg tid for 3 or 7 days + clindamycin 20 mg base/kg/day divided tid for 7 days. Severe malaria Adult & childn Quinidine gluconate 10 mg/kg loading dose IV over 1-2 hr, then 0.02 mg/kg/min continuous infusion for at least 24 hr. Once the parasite density <1% & patient can take oral medication, complete treatment w/ oral quinine dose + clindamycin 20 mg base/kg/day divided tid for 7 days; or 10 mg base/kg clindamycin loading dose IV followed by 5 mg base/kg IV every 8 hr if patient not able to take orally. Treatment course: 7 days. Prophylaxis of endocarditis in penicillin-sensitive patients Adult 600 mg 1 hr before procedure. Childn 20 mg/kg 1 hr before procedure. Alternatively, clindamycin phosphate 600 mg IV 1 hr before procedure when parenteral administration is required.

May be taken with or without food: Swallow whole w/ a full glass of water & in an upright position.

Hypersensitivity to clindamycin or lincomycin.

Discontinue if hypersensitivity or severe skin reactions occur. Pseudomembranous colitis & Clostridium difficile-associated diarrhea. Not for the treatment of meningitis. Perform liver & kidney function test in prolonged therapy. May result in overgrowth of non-susceptible organisms, particularly yeasts. Pregnancy & lactation.

Pseudomembranous colitis, Clostridium difficile colitis, vag infection; agranulocytosis, neutropenia, thrombocytopenia, leukopenia, eosinophilia; anaphylactic shock, anaphylactoid & anaphylactic reaction, hypersensitivity; dysgeusia; cardio-resp arrest; thrombophlebitis, hypotension; diarrhea, abdominal pain, esophageal ulcer, esophagitis, vomiting, nausea; jaundice; TEN, SJS, drug reaction w/ eosinophilia & systemic symptoms, acute generalized exanthematous pustulosis, angioedema, exfoliative dermatitis, bullous dermatitis, maculopapular rash, urticaria, erythema multiforme, pruritus, morbilliform rash; pain, inj site abscess, inj site irritation; abnormal liver function test.

May enhance neuromuscular blocking properties of neuromuscular blocking agents. May reduce clearance w/ CYP3A4 inhibitors. May increase clearance w/ CYP3A4 inducers.

Other Antibiotics

J01FF01 - clindamycin ; Belongs to the class of lincosamides. Used in the systemic treatment of infections.

Rx